Background/Aims:
Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides (TG), a concomitant increase in small dense (sd) low density lipoprotein (LDL) and atherogenic LDL-TG. Angiopoietin like protein 4 (ANGPTL4) is well established regulators of plasma TG level through regulating the activity of lipoprotein lipase. Plasma level and association between ANGPTL4 and sdLDL or LDL-TG is not well established in human subjects. We aimed to examine the level of ANGPTL4 and investigate the association between ANGPTL4 with sdLDL-C and LDL-TG in type 2 diabetes (T2D).
Methods:
250 (M176/F 74) Japanese diabetic patients and 9 of healthy controls (Controls) were enrolled in this study. SdLDL-C and LDL-TG were measured by homogeneous assays. ANGPT3 and ANGPT4 protein levels were measured by ELISA.
RESULTS: 
As compared with Controls, plasma ANGPT3, ANGPT4, sdLDL-C and LDL-TG levels were increased in T2D. ANGPT3 was not collated with sdLDL-C or LDL-TG. ANGPTL4 was positively correlated with HbA1c（r=0.15, p=0.019）, TG（r=0.15, p=0.018）and  LDL-TG（r=0.17、p=0.008）, whereas ANGPTL4 was not collated with sdLDL-C. Furthermore, ANGPTL4 was also significantly associated with LDL-TG/LDL-C ratio (r=0.15, p=0.022) and LDL-TG/apoB ratio (r=0.18, p=0.009).
Conclusions:
The ANGPTL4 level was increased in T2D and associated with atherogenic higher LDL-TG levels. ANGPTL4 may play a role in modulating lipid metabolism in LDL particles.

04 - INCREASED ANGIOPOIETIN LIKE PROTEIN 4 (ANGPTL4) IS ASSOCIATED WITH HIGHER CONCENTRATION OF LDL- TRIGLYCERIDES IN TYPE 2 DIABETES