In this report, we investigate the addition of p-toluenesulfonyl isocyanate (TsNCO) to electron-rich hydrocarbon alkenes and monoflouroalkenes to determine their ability to produce monofluoro-tosyl-β-lactam rings, and to determine if the reaction occurs via a Single Electron Transfer pathway. β-lactam rings are a common structural motif found in antibacterial agents and potential cholesterol-lowering drugs.

[2+2] cycloaddition of p-toluenesulfonyl isocyanate to hydrocarbon alkenes and monofluoroalkenes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.