PREVENTION OF DIABETES IN OBESE PATIENTS WITH PHARMACOLOGICAL V/S Lifestyle modification
Shah Smita , Saboo Banshi, Raval Vaishnavi , Dhruvi Hasnani
Dia Care Clinic, Ahmedabad ,INDIA

Introduction:
Obesity has assumed a great public health and clinical significance in our country. Obesity affects more than 20%  adult  Indians and central obesity leads to the classic epidemic of diabetes, hypertension, dyslipidemia and CHD.  Sedentary lifestyles, increased consumption of junk foods and cola culture are one of the few factors contributing to the increased prevalence of obesity. Obesity is one of the key factors which play a substantial role in the development of insulin resistance and diabetes.
Aim:
In light of the above reports, the present study was aimed at screening of obese patients for presence of diabetes through parameters like IGT (Impaired Glucose Tolerance) or IFG (Impaired Fasting Glucose) and prevention of diabetes in obese, non-diabetic patients using pharmacological and non pharmacological treatment.
Materials and Methods:
Patients who were obese and were non-diabetic were included in the study. Obese patients who had already developed diabetes were excluded from the study. Fifty four patients were included in the study. Patients were characterized as obese based on their weight and BMI values. The parameters observed in the study were gender ratio, prevalence in different age groups, family history of obesity and diabetes, current pharmacological treatment and lifestyle (diet, exercise, tobacco, smoking, alcohol). Based on results appropriate lifestyle modifications were recommended.
Results and Discussion: Results showed that out of fifty four patients, 27 patients were males and 27 patients were females. Patients were in the Age range of 23-57 years and the average BMI value was 30.589, average waist: hip ratio was 0.966. The family history pattern showed that female patients had a more significant presence of family history of diabetes as compared to male patients and hence were at a higher risk of developing diabetes. It was also observed that there was a significant reduction in weight in both male and female patients in both the treatments i.e. with and without medication. Similar results were observed in case of cholesterol values. Interestingly, the IFG values did not significantly increase during the course of treatment with and without medication. Hence, it can be observed that diet, and exercise can prevent onset of diabetes in obese patients and medication can be prescribed for obesity only if diet and exercise are not showing promising results. As compared to male patients, female patients have to be more aware regarding their obesity keeping in mind, the prominent presence of family history. 

Conclusions: Since obesity plays a pivotal role in the development of diabetes, prevention of obesity will not only help prevent diabetes but also decrease the incidence of cardiovascular complications resulting from diabetes as well as obesity itself.

Prevention of diabetes in obese patients with pharmacological V/S lifestyle modification