Introduction: Oxidative stress plays an important role in acute ischemic stroke pathogenesis and stroke severity. Oxidized low-density lipoprotein(ox-LDL) is considered an early marker of oxidative stress and lipid peroxidation. Lipid peroxidation produces oxidative modification of LDL, which stimulates the production of autoantibodies by B- cells producing anti-oxd LDL antibodies. Different epitopes and different types of antibodies of ox-LDL could represent a biological marker of oxidative stress and atherosclerosis. The aim of this study is to examine the correlation between ox-LDL antibodies and lipid peroxidation in ischemic stroke patient.
Methods: Blood samples were collected from patients (n=105) and healthy individuals (n=110) for routine biochemical and Malondialdehyde (MDA), Total cholesterol, Triglycerides, HDL, LDL and Oxd- LDL antibodies.
Results: The mean + SD age of the subjects and controls were 55.17 + 11.37 and 54.11 + 12.35 years. Male: Female ratio of subjects and controls was 3:1. Among stroke patient’s levels of MDA, total cholesterol and LDL cholesterol and anti-oxd LDL were higher than the healthy subjects (p=<0.05). Significant positive correlation was observed between plasma levels of MDA, total cholesterol, LDL cholesterol and the concentration of anti-oxdLDL in patients but not in the controls.
Conclusion:Elevated anti-oxdLDL and MDA suggest an increase in oxidative stress that would contribute to the development of atherosclerosis in stroke patients. The observed correlation of MDA with anti-oxdLDL indicates the relationship between free radicals and atherosclerosis in Ischemic stroke patients

AUTOANTIBODIES AGAINST OXIDIZED LDL AND LIPID PEROXIDATION IN ACUTE ISCHEMIC STROKE.