Objective To evaluate the change of NIHSS score in patients with acute ischemic stroke at baseline and dischanrge. Methods This was a study of multicenter stroke registration in our country,a total of 54 centers are involved. This study assessed the neurological deficit score (NIHSS) of patients admitted to hospital, corrected demographic data,health insurance type, clinical classification, risk factors, past medical history. Multivariate regression analysis was used to analyze the influence factors of NIHSS score on the outcome of discharge. Then changes in NIHSS with baseline at discharge and the relationship between NIHSS and MRS were compared. Results 5473 ischemic stroke patients were recruited. The NIHSS score at discharge was significantly lower than the baseline, with an average reduction of 1 points (a median of between the ages of four and a score of 0 to about 3)，The left lower limb movement was the most obvious. All items of NIHSS had influence on prognosis like:age, level of consciousness, consciousness level instruction, awareness of questioning, gaze, facial palsy,sensation, visual fields, limb movement, sensation, ataxia, dysarthria, language,extinction and inattention; multivariate regression analysis shows: facial palsy,the level of consciousness instruction, vision,Limb movement effects on the prognosis of patients. At the time of discharge NIHSS score decreased significantly compared to the baseline. Conclusion The NIHSS score at discharge was significantly lower than the baseline, with an average reduction of 1 points (interquartile range:0～3).

The change of the National Institute of Health Stroke Scale in patients with acute ischemic stroke at baseline and discharge and its prediction on prognosis