Among 47 patients participating in the study (66% girls, 34% boys) eighty-three per cent (83%) is with IGHD and seventeen per cent (17%) with PHP. It was revealed that before treatment, 36 patients had a significantly short stature (from –6 to –2.01 SDS); SDS of 11 pa-tients (2 of them with PHP) was from -1.9 to -1. At the time of diagnosis, the mean height SDS was -2.4 in children with IGHD, while after completion of treatment, SDS was -1,4; height SDS was -2.7 before treatment and -0.8 after completion of treatment in children with PHP. The largest values of STH maximum level according to stimulation tests (at least 2) was 6.8 ± 5.2 ng/ml in group of those with IGHD and 2.56 ± 1.65 ng/ml in group of those with PHP (p <0.05). At the time of diagnosis, IGF-1 was below normal range in 76.6% of patients, after completion of treatment it was below normal range in 46.68% of patients; at the same time, the IGF-1 level in the group of those with PHP was lower compared to the IGHD group (p <0.05) and were ob-served in 87.5% of children. After GH treatment completion, IGF-1 remained below reference values in 87.5% of patients with PHP. A lagging of the bone age from the passport in the IGHD group before treatment was 2 years 5 months ± 1 year 3 months, after treatment it was 2 years 5 months ± 2 years; while in the group with PHP it was 2 years 11 months  ± 1 year 4 months be-fore treatment and 3 year 7 months  ± 4 year 7 months after treatment (p <0.05). During MRI, the pathology of the pituitary gland and surgical interventions for tumor neoplasms were de-tected in 36.2% of the patients. The average dynamics of growth during the entire period of treatment in patients with IGHD is 6.9 ± 1.62 cm/year, while in patients with PHP it is  7.9 ± 4.3 cm/year (p <0.05). In addition to treatment with GH, 100% of patients from the group with PHP also received levothyroxine, 50% of those received hydrocortisone, 12.5% of such patients received desmopressin.

DIFFERENCES OF EFFICIENCY OF TREATMENT OF ISOLATED GROWTH HORMONE DEFICIENCY AND PANHYPOPITUITARISM IN CHILDREN IN REAL CLINICAL PRACTICE