Background

Dietary fiber rich fenugreek seeds Extract have exhibited cardio-protective, hypolipidemic and other health benefits. FurosapTM, an innovative & patented, 20% protodioscin enriched extract was developed from fenugreek seeds.

Aim
This study examined the sperm profile and morphology, sexual health, mood and mental alertness, and broad spectrum safety parameters of FurosapTM in addition to free and total testosterone levels, in 36 male type 2 DM volunteers with sexual dysfunction following supplementation over a period of 12 weeks.

Method
This one-arm, open-labeled, mono centric study was conducted in 36 male Type 2 DM volunteers (age:35 to 65 years) suffering with over a period of 12 weeks to determine the efficacy of FurosapTM (500 mg/day/subject) on sperm profile, sperm morphology, libido and sexual health, mood and mental alertness, and broad spectrum safety parameters in addition to free and total testosterone levels.

Results
80.5% of the study population showed improvements in sperm counts. Sperm morphology improved in13.9% of Type 2 DM volunteers. 88.8% of the subjects enrolled in the study demonstrated improvements in mental alertness and mood. Furthermore, cardiovascular health and libido were significantly improved in 86.1% participants. Extensive safety parameters were evaluated which included blood chemistry data. No significant changes were observed in liver function, kidney function and hemogram. Serum lipids too did not show deterioration.

Discussion
Overall, the results demonstrate that Standardized Trigonella foenum-graecum seed extract enriched in 20% protodioscin, is safe and effective not only in attenuating testosterone levels but also improves sperm profile, mental alertness, cardiovascular health and overall sexual performance in human subjects.

Efficacy of Trigonella foenum-graecum extract as protodioscin, in improving sperm profile in type 2DM males with SD