EVALUATION OF THE USE OF NON-SPECIFIC IMMUNOGLOBULINS IN BURNED PEDIATRIC PATIENTS 
OBJECTIVE
To evaluate the use and follow-up of the administration of non-specific immunoglobulins (Ig) in burned pediatric patients. 
METHODS
Retrospective observational study, including all pediatric patients with >10% burned surface area (BSA), who were hospitalized between August 2012 and March 2016. 
Different variables were registered: biodemografic data (sex, age, weight), burn data (mechanism and burned BSA) and Ig administration data (plasmatic levels, dose, date and number of administrations).  
RESULTS
Forty-eight patients were enrolled (20 female). The median age was 2 years (8m-15y) and the median weight was 12kg (7,5-67kg).  The 87,5% (42) of burns were caused by scald. The median BSA was 14,5% (10-50%).
Determination of IgG levels was made in 37 patients (77%). Twenty-two patients had below-normal levels and a median BSA of 20,5%. Patients with normal levels had a median BSA of 12%.  
Non-specific Ig (400mg/kg) was administered in 52% (25) of the patients. Nineteen of these patients had below-normal levels before the first administration. Seven patients achieved normal levels of IgG (2 with BSA >20%) after the first infusion but there were 4 patients (3 with BSA>20%) who still had below-normal levels. A new dose of Ig was administered in 3 of them. No IgG determination was repeated after the first infusion in 8 (42,1%) children.
Ig was not administrated in 23 patients. The determination of IgG was done in 12 (52,17%) patients and 3 had below-normal levels. 
CONCLUSIONS
There is a positive correlation between the BSA and the depletion of immunoglobulins.   
By analyzing the results, the authors recommend the determination of IgG levels 72 hours after burn in children with BSA>15%. Moreover, when Ig is administrated in patients with a BSA>20%, it should be necessary a new determination after a week.

Evaluation of the use of non-specific immunoglobins in burned pediatric patients