BACKGROUND: - Insulin resistance is an important risk factor for the development of type 2 diabetes and Prediabetes. There is considerable debate regarding the importance of Homeostatic model assessment 1-IR (HOMA1-IR) vs. Homeostatic model assessment 2-IR (HOMA2-IR) as a better predictor for Glucose tolerance.
OBJECTIVE: - To find correlations of HOMA1-IR and HOMA2-IR with fasting plasma glucose and postprandial plasma glucose for  prediction of glucose intolerance. 
METHODOLOGY: - Fasting and 2hr postprandial plasma glucose (Oral glucose tolerance test) were performed in 168 in subjects with high IRDS score. At the time of OGTTs, fasting serum insulin levels were measured for HOMA1-IR and 2hr postprandial serum insulin levels were measured to calculate HOMA2-IR. Anthropometry and clinical details of the study subjects were also recorded. HOMA1-IR was calculated using the formula Fasting insulin (IU/ml) x Fasting glucose (mg/dl)/ 405. HOMA2-IR was calculated using the formula 2hr postprandial insulin (IU/ml) x 2hr postprandial (mg/dl)/ 405 Effectiveness of HOMA1- IR and HOMA2- IR in prediction of glucose intolerance was assessed through their correlation (co efficient of correlation) with fasting and 2hr postprandial plasma glucose.
RESULT:-  
Mean age of the study subjects were 40.60±9.65 years. Mean fasting plasma glucose was 99.74±22.37 and 2hr Plasma glucose was 141.51±55.43.Mean waist was 93.1±11.62 Mean HOMA1-IR was 4.32±4.02 and HOMA2-IR was 23.50±21.05. HOMA1-IR showed strong correlation with fasting glucose (R=0.3 and p=0.00) and 2hr pp glucose (R=.46 and p=0.00) then HOMA2-IR showed with fasting (R=.07 and p=0.31) and pp (R=.3 and p=0.00). Also the correlation of HOMA1-IR was stronger with waist circumference(R=.27 and p=0.00) then HOMA2-IR (R=.25 and p=0.01)
CONCLUSION:-
HOMA1-IR better correlates with fasting and postprandial plasma glucose and measures of obesity then HOMA2-IR. Therefore HOMA1-IR should be preferred over HOMA2-IR for prediction glucose intolerance.

HOMA1-IR as a better predictor for glucose intolerance then HOMA2-IR