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May 10, 2018

ESPID 2018

IMPACT OF MODERATE VACCINATION RATE AGAINST ROTAVIRUS DURING 9 YEARS IN THE GASTROENTERITIS HOSPITALIZATION RATE

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Pardo, J.;

Cebey-López, M.;

Justicia-Grande, A.;

Rivero-Calle, I.;

Morillo-Gutiérrez, B.;

Redondo-Collazo, L.;

Rodríguez-Tenreiro, C.;

Salas, A.;

Martinon Torres, F.

vaccine

rotavirus

gastroenteritis

vaccination coverage

hospitalization rate

Abstract

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Keywords

vaccine

rotavirus

gastroenteritis

vaccination coverage

hospitalization rate

Abstract

Rotavirus (RV) vaccines were introduced in Spain between 2006 and 2007, and despite moderate coverage, it showed high effectiveness in the short term. We aim to evaluate the impact of moderate vaccination (22.3-49.3%) during 9 years in all-cause (AC) acute gastroenteritis (AGE) and RV-caused AGE hospitalization rates in Galicia (north-west Spain) in children younger than 5 years. In this ecological retrospective study, data have been obtained from Conjunto Mínimo Básico de Datos (CMBD; www.iasist.com) database. The study population considers children younger 5 years old admitted between July 2003 and June 2015. We have considered AGE (ICD-9 code from 001 to 009), and more specifically AGE caused by RV (RV-AGE, code ICD-9 008.6). Population data has been obtained from Instituto Galego de Estatística (www.ige.eu). Yearly hospitalization rates were analyzed excluding year 2007 (when the vaccine was introduced). A significant decrease in hospitalization rates was observed since RV vaccine introduction when comparing with the pre-vaccination period for children younger than 5 years old for both AGE (from 19.0% in 2014 to 50.3% in 2008) (Figure A) and RV-AGE (from 26.3% in 2014, to 51.1% in 2008) (Figure B). In the last years the magnitude of this decrease is smaller, which could be related to different factors from test sensibility to duration of herd protection or disease seasonality. Vaccination against RV, even with moderate -but sustained- vaccination coverage, shows a high effectiveness in relation to hospitalization by AGE and RV-AGE. The present study reinforces the convenience of including RV vaccine in the Spanish immunization schedule.

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All rights reserved.