Background: Diabetes mellitus is a complex syndrome characterized by disturbance in metabolism of carbohydrate, fat and protein metabolism. Dyslipidemia, a forerunner of majority of macrovascular and microvascular events contributes significantly to morbidity and mortality among diabetics. Although, a wide of drugs are available for the management of dyslipidemia that improve quality of life of diabetics, however they exert their own troll through direct(drug related side effect) and indirect(financial and psychological) means. Recently, some studies have shown antidiabetic and hypolipidemic effect of Syzygium cumini seed powder which is mostly attributed to saponins, glycosides and flavonoids. Aim: The present study aim to evaluate the impact of Syzygium seed powder on dyslipidemia of type 2 diabetics. Methods: 99 type 2 diabetics who were on OHA were selected based on predefined inclusion and exclusion criteria. These diabetics were randomized into 2 groups i.e. group A and B such that group A received 10 gm of Syzygium powder  in 2 equally divided doses prior to meal whereas group B received placebo. Patients and investigators were blinded regarding the treatment allocated. Baseline investigations including complete lipid profile were noted and were repeated on 30th, 60th and 90th day. Relevant statistical test were applied and analyzed. Results: A statistically significant improvement in various parameters of lipid profile was usually noticed on 60th day post commencement of medication (p<0.05). On comparison of the data from the baseline, it was noticed that mean cholesterol reduced by 10.55% (p<0.05) and 15.79% (p<0.001); TG reduced by 8.28% (p<0.05) and 13.66% (p<0.001); LDL-c reduced by 10.29(p<0.05) and 13.69% (p<0.05) on 60th and 90th day post commencement respectively. Although, an increment of 5.43% and 7.97% were noted in HDL-c values post 60th and 90th day however these were not statistically significant (p>0.05). Similarly, no statistically significant improvements were noticed in lipid profile post 30th day of therapy (p>0.05). Conclusion:  A significant impact of S cumini seed powder supplementation was found on dyslipidemic status of type 2 diabetics. Although the impact was variable on various components but in developing countries like India where financial status of patient plays a critical role in determining the choice of therapy, supplementation of S cumini  seed powder can be a boon in improving the metabolic profile of diabetics without further increasing financial constraints. Hence S cumini seed powder can be used as adjuvant therapy in reducing the morbidity due to microvascular and macrovascular complication of diabetes.

Impact of Syzygium cumini seed powder on dyslipidemia in type 2 diabetics: A double blind randomized control trial