Background: Stroke is the second cause of death in Chile, accounting for 10% of all deaths. There is significant regional variability in mortality and case-fatality rates, being particularly high in the southern Ñuble region, and lower in the northern region were the only previous community stroke study was performed (PISCIS study). This has been explained by differences in the prevalence of poverty, sedentary life-style, obesity and diabetes and significant variability in hospital care.
Aim: To present incidence data of the ÑANDU community stroke project. 
Patients and Methods: This prospective community study was organized per the STEPS/STROKE methodology. Hot and cold pursuit using multiple overlapping sources of hospitalized, ambulatory and deceased cases, with standardized diagnostic criteria were used to identify and follow-up all possible strokes-cases occurring in the resident population of Ñuble during one year. A program of community information and training of local health personnel using evidence-based protocols was implemented simultaneously.  Approval was obtained from the appropriate ethics committees.
Results: Cases were ascertained from 03-31-2015 to 03-31-2016. All cases had 1 year follow-up. 1004 first-ever stroke were ascertained. 50.0% were women and 79.8% were ischemic stroke. Mean age was 71.1 (14.6) for women and 68.7 (SD 13.5) for male. One month case-fatality rate was 13.3%. The age-adjusted annual incidence rates of first-ever stroke was 101.1 per 100,000 population. 
Conclusion:These results show several significant differences with the previous population stroke study in Chile. Particularly a higher incidence rate of stroke, older age of onset and higher proportion if ischemic strokes.

INCIDENCE OF STROKE IN A HIGH CARDIOVASCULAR RISK POPULATION IN CHILE: THE ÑUBLE REGION, CEREBROVASCULAR ATTACK INCIDENCE AND DEATH COMMUNITY SURVEILLANCE AND INTERVENTION STUDY (ÑANDU)