Background: Dermoscopy is a convenient tool to diagnose melanocytic lesions, especially nevus and melanoma. Various pigmented structures, including pigment network, dots and globules, and streaks, are observed in dermoscopy. Usually, 2D vertical images are used to explain the correlation of dermoscopy and histopathology. However, since the image of dermoscopy is horizontal, it is difficult for beginners to understand the horizontal view of dermoscopy by the vertical view of histopathology. 
Objectives: To provide the better understanding for dermoscopy-pathology correlation in the pigmented skin tumors.
Methods: We digitally reconstructed 2D top-down horizontal view images and 3D aerial images from 50-100 serial 2D vertical sections of melanoma and nevi by using high-speed scanner and 3D software. 
Results: 2D top-down horizontal view images and 3D aerial view images successfully revealed the histopathological structures including network of rete ridges, accumulated melanin in cornified layer, nests in dermal epidermal junction, polygonally dilated network of rete ridges like honeycomb which is filled with nests of pigmented cells, and confluently connected nests of pigmented cells, correspond to the dermoscopic structures in network, dots, globules, cobble stone pattern and streak, respectively.
Conclusions: We successfully showed the histopathological and dermoscopic correlation in a new method.

An intuitive explanation of dermoscopic structures by digitally reconstructed pathological top-down view and 3D images