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Metastasis of Cervical Cancer to the Abdominal Wall: a case report


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Presented at

ESGO State of the Art 2018 Conference





Introduction Squamous cell carcinoma of the cervix (SCC) accounts for 85% of the cases of cervical cancer. The most common sites of recurrence postoperatively are in the pelvis and vagina. Metastases to the abdominal wall from cervical carcinoma are rare with a reported incidence of 0.1 to 2 %, and a survival rate ranging from 1 week to 7 months. Case report A 43-year-old woman with stage IB2 SCC of the cervix underwent a radical hysterectomy, with bilateral salpingo-oophorectomy and pelvic lymph node dissection at a different institution. She did not receive any adjuvant treatment, although she is considered at intermediate risk by Sedlis criteria (size of 4 cm and deep stromal invasion). Fifteen months later, she presented to our institution with a painful suprapubic rapidly growing mass. MRI of pelvis showed a 13 x11x 9 cm mass adherent to the anterior abdominal wall, to the dome of the bladder and to the small bowel with enlarged right pelvic lymph nodes. There was no evidence of intra-abdominal or distant metastases. The mass was removed en bloc, with rectus abdominus muscles, 2 segments of small bowel and a portion of the bladder, along with right pelvic lymphadenectomy. The resultant infra-umbilical abdominal wall defect measured 20 x 15 cm. It was reconstructed with an island pedicle of right thigh anterolateral vastus and vastus lateralis muscle flap. Histology showed invasive non-keratinizing moderately differentiated SCC, consistent with uterine cervical primary, involving urinary bladder, bowel and soft tissue, with negative margins and one positive right pelvic lymph node. Adjuvant treatment was delayed for 3 months to allow for complete healing as the patient had to undergo de-epithelialization of a segment of the flap. She received 6 cycles of Carboplatin, Taxol and Avastin and was then lost to follow up for 4 months. CT scan confirmed the absence of recurrence and she is currently receiving the pre-planned radiation therapy. She remains free of recurrence after 12 months of the surgery. Discussion We describe the case of a 43-year-old woman with abdominal wall lesion that turned out to be metastatic from primary cervical carcinoma. Metastatic carcinoma to the abdominal wall is uncommon. Treatment involves chemotherapy and/or radiotherapy. Two cases in the literature are similar to our case, and treatment consisted of palliative resection of the abdominal wall lesion, followed by reconstruction with various muscular flaps. Recurrence is deemed to be the result of residual occult cancer after surgical resection. Other mechanisms of spread proposed are through implantation of cancer cells at the time of surgery or via retrograde spread through the lymphatics. Conclusion The present case is uncommon because abdominal wall metastasis from SCC of the cervix after radical surgery is rare. It was also challenging since the removal of the lesion has resulted in a large soft tissue defect. However, with advancement in reconstructive surgery, extensive resection with defect closure with rotational flaps may be the standard of care in the management of abdominal wall lesion after cervical cancer in order to improve the overall survival.


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© Copyright 2020 Morressier GmbH.
All rights reserved.