Objective: Analysis of the different therapeutic options available today for the management of muscular - skeletal pain derived from AI treatment, to the treatment of a frequent problem and of great importance today. Note of the effectiveness of its use in each case and the level of evidence of the studies that propose them.
Material and methods: Review of the literature in the main databases, by searching for articles published in the last 10 years, in Spanish or English. Selection of these published articles on clinical trials, reviews or meta-analyzes that propose management strategies or therapeutic interventions for AI-induced symptoms in women with early-stage breast cancer, who subsequently underwent an evaluation of their methodological quality
Results: Analyze the studies that obtained the highest level of methodological quality obtained. Thus, clinical trials frequently included the beneficial effect of duloxetine, omega three fatty acids, vitamin D2 at doses of 50000UI daily and acupuncture respectively, in a statistically significant way, when compared with placebo, demonstrating higher pain reduction rates in the groups that received the intervention. In systematic reviews and meta-analysis, it states that the interventions with the greatest effect on symptom control are pharmacological treatment and acupuncture, while those with the least effect are physical exercise and nutritional supplements. One of the meta-analyzes included states that there is no statistically significant effect of acupuncture on the control of symptoms caused by AI.
Conclusion: Despite the great diversity of strategies proposed for the control of these symptoms, few quality studies have been published. In addition, published studies lack a sufficient level of evidence to support the creation of a therapeutic guide for the management of AI-derived syndrome that allows a unique, coordinated and agreed approach to the subject.

MUSCULOSKELETAL CHRONIC PAIN ON PATIENTS WITH BREAST CANCER TREATED WITH AROMATASE INHIBITORS. AN ANALYSIS AND EVALUATION OF THE CONVENTIONAL THERAPEUTIC APPROACH