<br/>The frondosin family of natural products, consisting of five compounds A-E, was first isolated in 1997 from the marine sponge <i>dysidea frondosa</i>, and they have been determined to have anti-inflammatory, anti-tumor and HIV- inhibitory activity. There is currently no synthetic pathway for the total synthesis of frondosin D. This study explored two distinct pathways for the synthesis of the tetracyclic structure of frondosin D. Both of the explored approaches include a 7-membered ring tricyclic compound as the key intermediate which can be obtained via tandem 5-exo dig cyclization/Claisen rearrangement methodology developed by the Ovaska group.

Progress towards the total synthesis of frondosin D via tandem cyclization/claisen rearrangement

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.