Prospective randomized double blinded placebo controlled study to assess the efficacy of single dose intranasal dexmedetomidine in attenuating the hemodynamic response to endotracheal intubation
Author(s):
Rajendran M., Sheena Cherry B., Madhumitha M.
Institute(s):
RG Stones, Dept of Anaesthesiology, Chennai, India
Text:
Background and Goal of Study: The aim of this study is to prove the efficacy of single dose intranasal dexmedetomidine in attenuating the intubation response.
Materials and Methods: The study was conducted at Sri Ramachandra Medical College and Research Institute between DEC 2011-SEP 2012 after getting the ethics committee approval. 
This is a prospective, placebo controlled, randomized, double blinded study.
The sample size was determined as 30 per group by Power analysis with alpha error of 0.01 and beta error 0.8. 60 subjects were enrolled in our study.
Results and Discussion: The pre induction mean of mean blood pressure in group A was 84.13±5.13mm of Hg and 86.17± 6.29mm of Hg in Group B which was not significant with a p value of .176.
The pre intubation mean of mean blood pressure in group A was 79.83±4.57mm of Hg and 85.67±7.75mm of Hg in group B which was significant with a p value of 0.001
The post intubation mean mean blood pressure at 0 minute was 80.73±3.48mm of Hg in group A and 105.70±8.76mm of Hg in group B with a p value of 0.000 which is highly significant.
The mean of mean blood pressure at 3, 5 were also highly significant with p value 0.000 between the two groups.the mean of mean blood pressure at 10 minutes also had a significant p value of 0.001.
The pre induction mean heart rate in group A was 70.57±4.88 and 75.27±8.60 in group B which was significant with a p value of .025.
The pre intubation mean heart rate in group A was 69.10±6.59 and 75.33±9.64 in group B which was significant with a p value of 0.002.
The post intubation mean heart rate at 0 minute was 69.47±6.59 in group A and 93.20±7.65 in group B with a p value of 0.000 which is highly significant.
The mean heart rates at 3, 5 , 10 minutes were 70.23, 69.10, 68.23 in Group A and 85.23,80.03,75.40 in Group B with p value 0.000 between the two groups.
60 patients were enrolled in the study and the observations made were analyzed using the SPSS software. The results were expressed as mean, standard deviation and percentage. A p value< 0.05 was considered significant.
Conclusion(s): In our study usage of dexmedetomidine given intranasally at a dosage of 1mcg/kg, 30 minutes prior to the procedure with succinyl choline attenuates the hemodynamic response to intubation.
Ethical Research Declaration:
1. Prospective observational only studies
Preferred Presentation Type:
Clinical or experimental study

Prospective randomized double blinded placebo controlled study to assess the efficacy of single dose intranasal dexmedetomidine in attenuating the hemodynamic response to endotracheal intubation