Cationic Liposomes (CLs) are synthetic vectors for nucleic acid (NA) and drug delivery applications. CLs may be complexed with nucleic acids (DNA or short interfering RNA) for gene delivery and silencing, or used as vectors of cytotoxic hydrophobic drugs in cancer therapeutics. Primary among hydrophobic drugs is paclitaxel (PTX) a mitotic inhibitor that halts the proliferation of tumor cells during the cell cycle and induces cell death. We will describe the effect of PEGylation of paclitaxel-loaded cationic liposome (CLPTX) nanoparticles (NPs) on structure and NP shape, which, in turn, lead to modified interactions with human cancer cells and a dramatic enhancement of PTX delivery and cytotoxicity compared to bare CLPTX NPs. This enhancement occurs even though the PEG-chain coating the NP is in the mushroom to brush transition regime. These results are in contrast to PEGylated CL-DNA NPs employed in gene therapeutics, where the PEG coat suppresses cell entry.

Structure and shape transitions in PEGylated paclitaxel-loaded cationic liposomes enhances delivery and cytotoxicity to human cancer cells

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.