Natural remedies are rising in popularity as a way to promote weight loss. Research has found that green coffee bean extract has decreased fat accumulation in model organisms including in the nematode, Caenorhabditis elegans. This supplement is anecdotally used in humans and is proposed to be a weight loss intervention. Our lab is interested in studying the validity of this supplement as an option for combating excess weight gain and obesity, and to define the mechanisms behind how green coffee bean extract is impacting overall fat metabolism. Our lab developed novel stable isotope labeling strategies to trace fat origin via mass spectrometry and thus allows us to determine the amount of fat synthesis and fat absorption in an obesity model. Our lab is currently analyzing the impact of green coffee bean extract on normal wildtype animals at different concentrations to determine mechanisms by which overall fat storage is reduced. Furthermore, we are using genetic mutants to define the pathways which are crucial for the decrease of fat storage. Prior studies have shown a correlation between fat storage and longevity, and, in fact, green coffee extract has been purported to extend lifespan in C. elegans. Our lab hopes to understand the relationship between the fat storage and longevity pathways that may be used under green coffee bean extract supplementation.

Supplementation of green coffee bean extract in C. elegans

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.