Background and Purpose: The simplified stroke-thrombolytic predictive instrument (s-Stroke-TPI) is useful for predicting the outcomes in thrombolysis-treated patients in Western populations. We aimed to validate its predictive value in Chinese patients.
Methods:  Data from thrombolysis implementation and monitor of acute ischemic stroke in China were analyzed. Patients with acute ischemic stroke and treated with thrombolysis within 4.5 hours of symptom onset were included. The 3-month functional outcomes were assessed with the modified Rankin scale. Model discrimination was quantified by calculating the area under receiver operating characteristic curve. s-Stroke-TPI was compared with dense artery sign, Rankin score, age, glucose, onset to treatment time, and NIHSS or stroke prognostication using age and NIHSS.
Results: A total of 1102 patients who received thrombolysis were enrolled. The area under receiver operating characteristic curve of s-Stroke-TPI for predicting a catastrophic outcome (modified Rankin scale, 5–6), a normal/near-normal outcome (modified Rankin scale, 0–1), and independent outcome (modified Rankin scale, 0–2) at 3 months were 0.80, 0.73, and 0.75, respectively, which were significantly higher than or similar to those of dense artery sign, Rankin score, age, glucose, onset
to treatment time, and NIHSS or stroke prognostication using age and NIHSS. The calibration analysis of the s-Stroke-TPI   showed a high correlation between the predicted and observed probabilities of the functional outcomes at 3 months.
Conclusions: The s-Stroke-TPI reliably predicted the 3-month functional outcomes, especially catastrophic outcomes, in Chinese stroke patients with thrombolysis. Further validation is needed to confirm outcome predictions in patients both with and without thrombolysis.

Validation of the Simplified Stroke-Thrombolytic Predictive Instrument among Chinese Patients with Reperfusion Therapy