Y90 embolization has become an established treatment for a variety of hepatic malignancies for both loco-regional therapy and as a bridge to transplant.
The release of beta radiation is the primary mechanism. This leads to radiation necrosis, which is different to the coagulative necrosis seen with conventional embolization.
As a result of the different pathophysiology of cell death, the post-treatment appearances on contrast-enhanced CT can be varied, and challenging to interpret
The expected onset and duration of a selection of frequently encountered post-treatment appearances is described, along with pictorial examples, to aid the reporting radiologist in separating expected post-treatment change from either residual and/or recurrent malignancy and treatment complications.

Yttrium-90 Radioembolization: Expected and Unexpected Findings