Resorbable membranes are usually used in guided bone regeneration procedures. They present many advantages: no need for membrane-removal surgery; a wide range of surgical applications; a better cost-effectiveness; and a decreased in patient morbidity. However, the difficulty of maintaining the barrier function for an appropriate length of time is considered a major drawback for resorbable membranes. In addition, the resorption process of the membrane may interfere with wound healing and affect the volume of regenerated bone.
The objective of this study is to analyse the healing of soft tissue over a period from one to four weeks when using a synthetic resorbable membrane in various guided bone regeneration situations.
Ninety-three patients requiring a guided bone regeneration procedure were included in this study. A synthetic resorbable PLGA membrane with various bone substitutes were used in alveolar preservation, bone augmentation before implants or bone regeneration during implantation. After 1 and 4 weeks post-surgery, the early wound-healing index (EHI) was scored.  
After 1 week, a primary flap closure without exposure of the membrane was observed in 68% of cases. When the flap was well closed initially, the wound was completely healed in 86% of cases. At four weeks, 97% of cases had complete mucosal healing regardless of the initial situation. 
This clinical study shows the safety and performance of a new synthetic resorbable membrane. When the membrane was initially exposed, it kept its integrity without loss of the biomaterial granules and without infection. In most cases, the complete soft tissue healing occurred at four weeks without problems.

Soft tissue healing process with the use of a new resorbable synthetic membrane