Background: Diabetics often have reduced performance in numerous domains of cognitive function, a process termed as “Diabetic encephalopathy”. The exact pathophysiology of cognitive dysfunction in diabetes is not completely understood, but it is likely that hypoglycemia, vascular disease, insulin resistance and even hyperglycemia play significant roles in development of diabetic encephalopathy. Although cognitive dysfunction is quite common in elderly, however, its occurrence in non-elderly diabetics is relatively less and also not much investigated. Aim: To identify the correlation among various components of lipid profile with mild cognitive impairment in non-elderly type 1 diabetics. Methods: 196 type 1 diabetics justifying relevant inclusion &exclusion criteria were tested using a predefined questionnaire. Anthropometric indices, biochemical and clinical parameters were measured. MoCA test was employed for the assessment of cognitive dysfunction. Receiver operating characteristic, partial correlation, and logistic regression analyzes were employed for evaluation. Results: 71.42% of enrolled diabetics had some degree of cognitive dysfunction. Duration of the disease had a significant impact on cognitive functioning (p=0.032).Gender, residential area as well as the age of onset of diabetes appeared to have an insignificant impact on cognitive functioning (p>0.05). Diabetics with poor glycemic control were more prone to develop MCI (p<0.001).On comparison of various component of MoCA test; it was seen that most significant parameter that was affected was attention (p<0.001), followed by delayed recall /memory, naming and abstraction (p<0.05).Conclusion: The results of our study suggest that dyslipidemia chiefly raised total cholesterol, triglycerides and LDL is quite common in non-elderly type 1 diabetics and are associated with poorer cognitive function. Cognitive dysfunction should be listed as one of the many complications of diabetes, along with retinopathy, neuropathy, nephropathy, and cardiovascular disease in the future

The spectrum of mild cognitive impairment in dyslipidemic non-elderly type 1 diabetics