Objectives:
Scedosporium apiospermum infections are an emerging cause of invasive disease both in immune-compromised as well as immune-competent individuals. Therefore, the primary objective of this study was to ascertain the spectrum of infections, predisposing factors, treatment and outcomes of patients suffering from Scedosporium apiospermum infections attending outpatient clinics or admitted to our hospital.

Methods:
This was a retrospective study of three years from January 2015 to December 2017. All cases of infections due to Scedosporium apiospermum were included in the present study. Demographic characteristics, clinical and laboratory data, and mycological examinations were analyzed.

Results:
During the study period, a total of eight cases were identified. The mean age was 49 years (range of 2-78 years). There were five male and three female patients. Five of the eight cases presented with pulmonary symptoms. Of these two patients were known cases of HIV (2/5), two had COPD being treated with steroids (2/5) and one case had silicosis (1/5). There were two cases of invasive sinusitis and both the patients had no underlying condition. There was one case was of B cell acute lymphoblastic leukemia (ALL) who presented with acute suppurative otitis media with mastoiditis. Six of the eight cases were treated with voriconazole and had a successful outcome

Conclusion:
Scedosporium apiospermum is a highly pathogenic fungus which has potential to cause angio-invasive disease and fungemia. The burden of such cases is ever increasing. An early diagnosis with correct identification to the species level helps in initiation of accurate therapy with voriconazole.

Spectrum of Scedosporium apiospermum infections in a tertiary care centre in North India: Experience over three years