Introduction: Clioquinol was firstly produced in 1934 as antiseptic.We confirmed the antifungal function of clioquinol was strong and broad in former experiment of our team. 
Objective and Methods: We tried to find the clue of target through morphologic change after Candida albicans treated with clioquinol. The observation under fluorescence (FM) and scanning electron microscope (SEM) was conducted after 7 days. 
Results: When observed under SEM, the surface of spores was smooth and no depression and fissures were seen in control groups. As for ATCC10231, fluorescence intensity weakened and hyphae formation decreased in clioquinol group (4 µg/ml). Surface depressed in parts of spores with no fissures under SEM (Fig. 2). When the same method was used in C. albicans clinical strain, Obvious decrease of fluorescence intensity and hyphae formation was found in clioquinol group at 8 µg/ml. As for observation under SEM, most spores depressed and distinct fissures seen in parts of spores (Fig. 3).
Discussion: When C. albicans was treated with clioquinol at 0.5 MIC, obvious changes in morphology were observed under FM and SEM.

Observation of Candida albians treated with clioquinol monitered under fluorescence and scanning electron microscope