Background and Goal of Study: The addition of Background and Goal of Study: The addition of droperidol to patient-controlled analgesia (PCA) is the current gold standard prophylactic anti-emetic in fentanyl-associated postoperative nausea and/or vomiting (N/V). Even when droperidol is added to the PCA, some patients complain of N/V. We aimed to assess whether prophylactic intravenous prochlorperazine (PCZ) at the end of surgery could prevent N/V during intravenous PCA (IV-PCA) with fentanyl.
Materials and Methods: We retrospectively studied 74 patients administered IV-PCA immediately after surgery from February to August 2016. IV-PCA was prepared with fentanyl 15 mcg/ml and droperidol 40mcg/ml, and was set to provide 1ml/hour plus a bolus dose of 1ml with a lock-out period of 10 min. Of the 74 patients, 39 were also administered a single dose of PCZ 5mg immediately after surgery (Group A) and 35 were not (Group B). All patients were followed for the first 24 hours. Patients could request a single dose of PCZ whenever they experienced N/V. The number of patients with, and the number of times that PCZ was requested were documented during two time periods, 0-12 hours and 12-24 hours after surgery. Chi-squared test and Student's t-test evaluated the difference between the two groups; p <0.05 was significant.
Results and Discussion: The number of patients with N/V was 2 (5.1%) in Group A and 9 (25.7%) in Group B during 0-12 hours, and 5 (12.8%) in Group A and 5 (14.7%) in Group B during 12-24 hours after surgery.The difference in the number of patients experiencing N/V in the first 12 hours was statistically significantly different between the two groups, however, not for the 12-24 hour period (p=0.028 and p=1.00, respectively). The mean number of times PCZ was requested was also statistically significantly different during 0-12 hours, however, not for the 12-24 hour period (p=0.02 and p=0.67, respectively). 
Conclusion(s): Our experience suggests that prophylactic intravenous PCZ at the end of surgery may be effective for preventing nausea and vomiting during fentanyl IV-PCA in the first 12 hours after surgery.


01 / Assessment of prophylactic intravenous prochlorperazine at the end of surgery for prevention of nausea and vomiting during intravenous patient-controlled analgesia with fentanyl
