Background and Goal of Study: traumatic spine surgery is associated with major blood loss for which it is often necessary to be transfused. Many techniques blood saving are developed in order to limit bleeding and consequently transfusion. We assessed whether tranexamic acid (ATX) would reduce the accumulated blood loss over 24 hours without the occurrence of side effects

Materials and Methods:120 patients operated on for traumatic spinal arthrodesis of three to five vertebrae were included. They were divided into two equal groups of 60 patients each: Control (T) and Exacyl (E). The group E received Exacyl (ATX) intraoperatively and postoperatively until the fifth hour (10 mg / kg bolus followed by 1 mg / kg / h). We evaluated the intraoperative and postoperative blood loss until the 72th hour. we searched the occurrence of side effects and changes in laboratory parameters from dosing of ddimers and I trponine every 8 hours during the first day.A Doppler ultrasonography of the lower limbs was performed for all patient with a rate of d-dimer> 10.000ng / ml. statistical analysis by SPSS 22

Results and Discussion:

there is no difference between the anthropometric parameters of the 2 groups

 
	T	E	p
Duration of the act (min)	112.4± 22.8	128.7± 29.9	0.14
duration of anesthesia (min)	154.7± 37.7	161.7± 41.2	0.17
number of operated vertebrae	3.92 ± 0.84	4.08±0.60	0,31
bleeding in post- interventional	782.6± 234.7	644.9± 288.7	0.044
monitoring room (ml)	442.7± 185.6	312.8± 88.4	0.031
transfusion rate(RBC)	0.96 ±0.24	0.78 ±0.31	0.27
D-dimer (ng / ml)	3968 ± 147	5847 ± 2545	0.022
TroponineI (μg / l)	0.058 ± 0.033	0.074 ± 0,027	0.09


we have noted in any patient of the 2 groups the occurrence of clinic or doppler ultrasound thromboembolic complications

Conclusion :ATX significantly reduce blood loss in the traumatic spinal surgery, with no impact on transfusion and no significant side effects


03 / Intrest of tran,examic acid in the prevention of bleeding during surgery TRAUMATIC SPINE