Background & Aims: We aimed to explore the effect of an alcohol-free beer with modified carbohydrate composition (almost completely eliminating maltose and adding isomaltulose (16.5 g/day) and a resistant maltodextrin (5.28 g/day) in comparison to a regular alcohol-free beer on glycemic control of diabetic subjects with overweight or obesity.
Design: We randomized 43 subjects into two groups: a) consumption of 66 cL/day of regular alcohol-free beer for the first 10 weeks and 66 cL/day of alcohol-free beer with modified carbohydrate composition for the next 10 weeks; b) the same described intervention in opposite order. There was a washout period for 6-8 weeks between the two interventions. Participants were counselled to adhere to a healthy diet for cardiovascular health and to increase physical activity. Clinical, biochemical, anthropometric, lifestyle and satiety assessments were performed at the beginning and at the end of each period.
Results: Subjects showed significantly weight loss after the two periods (-1.69±3.21%  and -1.77±3.70% after experimental and regular alcohol-free beers, respectively, P=0.881). Experimental beer led to higher and statistically significant change in insulin, HOMA-IR and glycated hemoglobin (P=0.043, P<0.001 and P=0.001, respectively) that remained significant after confounding factors adjustment, except for glycated hemoglobin. Glucose levels did not significantly change in any phase. Subjects reported higher satiety scores after consuming experimental alcohol-free beer.
Conclusions: An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of a resistant maltodextrin within meals led to an improvement in insulin resistance in subjects with T2DM and overweight or obesity.

01 - EFFECT OF AN ALCOHOL-FREE BEER ENRICHED WITH ISOMALTULOSE AND A RESISTANT DEXTRIN ON INSULIN RESISTANCE IN DIABETIC PATIENTS WITH OVERWEIGHT OR OBESITY.