Inflation of perfluorocarbon (PFC) nanobubbles (NBs) and microbubbles (MBs) when exposed to liquid PFC nanodroplets (NDs) was recently discovered by our group. While preliminary experiments demonstrated the feasibility of our novel approach in vitro and in vivo, its translational success will rely on our ability to control bubble inflation. Limiting the extent of inflation is critical to safely improve either tumor detection using NBs or to occlude tumor microvasculature with high specificity using MBs. This presentation will describe the impact of different formulation parameters on the extent and rate of MB growth as well as translational opportunities. We demonstrated that both rate and degree of expansion are affected by the type of PFC used, ND and NB/MB size and the type of lipid emulsifier. Interestingly, limiting the ultimate size of inflated MBs was only possible when using a polymeric MB shell as opposed to phospholipids. We believe that these accomplishments show promises and potential to translate our novel approach to the clinic while creating new paradigms for early detection and treatment of cancer. As this non-invasive platform can be used to perform chemoembolization as is currently done to treat liver tumors, one of our current goals is to load chemotherapeutics in NDs or MBs and promote drug release specifically in tissues expressing the receptor of interest, analogous to trans-arterial chemoembolization. Furthermore, since this approach is not image guided, tumors will not need to be visible pre-treatment.

Controlled microbubble inflation and drug release using perfluorocarbon nanodroplets

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.