Cyclic peptides have undergone a renaissance in medicinal chemistry. Defying the decades-old assumption that peptides are hopelessly un-druglike, more and more cyclic peptides are being discovered with surprisingly high passive permeabilities and, in some cases, drug-like oral bioavailability.  While we understand the general factors governing ADME properties in cyclic peptides, the question remains: Can we harness that understanding to generate molecules that are both membrane permeable and capable of inhibiting a given therapeutic target? I will describe new results from our efforts to translate our understanding of permeability in this interesting class into molecules with therapeutic potential.  <br/>

Discovery of bioactive, passively permeable cyclic peptides: Translating theory into practice

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.