Understanding the interactions betwen the drug and dye molecules with the lipid membranes is crucial in cell imaging, designing new drugs and drug delivery vesicles. Recently, we used second harmonic generation method with interface selective and fluorescence spectroscopy to investigate the adsorbing, aggregating, embedding and cross-membrane transporting of some dye and drug molecules on the surface of vesicles [1, 2]. Based on these studies, we found that the the ionic strength in the aqouoes solutions notablly influenced the adsorption and transportation behaviors of molecules on the vesicle surface. This proved that the majority of species in the cross-membrane thansportation was charged form instead of neutral form. Also, we found that the anticancer drug, doxorubicin, formed molecular domains at the lipid interfaces. At high doxorubicin concentrations, these domains altered the pemeability of the membrane.<br/><br/><br/>

Dynamic behavior of molecules on the lipid membranes studied with second harmonic generation and fluorescence

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.