Polysaccharide-based hydrogels are a particularly fascinating family of materials due to their singular properties such as low cytotoxicity, hydrophilicity and mechanical strength. Among the catalogue of polysaccharides, alginate, which is extracted from seaweed, has been clearly the most employed biopolymer in current biomedical applications. However, alginate hydrogels have some mechanical and biological restrictions, namely structural degradability and poor cell-adhesion. These limitations are usually overcome via blending with cell-adherent molecules or other biomaterials. An example of such materials includes protein nanofibrils that present excellent properties in terms of mechanical strength and stability, but also antimicrobial and cell-adherent activities, and their use as building nanoblocks in innovative functional nanocomposites has attracted increasing attention.<br/>In this sense, the present study is focused on the development of new nanocomposite alginate-based hydrogels reinforced with protein nanofibrils, in order to produce hydrogels with improved mechanical performance and cell viability for application in the biomedical field, for example in tissue engineering and development of bioinks for 3D-bioprinting.<br/><br/>

Polysaccharide-protein nanofibers reinforced hydrogels: Production, characterization and potential applications

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.