In this talk, we will discuss our recent work on the design of responsive and moldable hydrogels formed via dynamic covalent or supramolecular interactions. Our lab has focused on fundemental insight into the polymer physics of ideal reversible networks and how chemical details of the junction points dictate emergent macroscale properties. In addition, we have advanced the design and understanding of colloidal biomaterials formed via tailored polymer–nanoparticle interactions. In each case, we have exploited this understanding to engineer dynamic hydrogels for a range of biomedical applications. Dynamic covalent hydrogels formed from reversible boronic ester cross-links were exploited for the thermal stabilization of complex biologics. This approach enabled encapsulation and storage of enzymes, therapeutic proteins, and vaccines with retained activity across a broad range of temperatures and storage times. Normally, these molecules spoil when stored outside of 2-8 C. At the time and point of use, the stabilized biomolecules were released from the reversible network. Polymer–nanoparticle hydrogels were exploited to design a universal nano-carrier platform for the design of functional bioinks for additive manufacturing and bioprinting. The materials were designed with suitable shear-thinning and self-healing properties for extrusion-based printing and the inclusion of secondary polymers enabled post-printing stabilization and biofunctionality for tissue engineering and drug delivery applications. Overall, this talk will provide our view on how fundamental macromolecular chemistry and engineering can be exploited to design biomaterials through precise control over dynamic cross-links.

Macromolecular engineering of responsive biomaterials via dynamic cross-links

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.