Drugs resistance by cancerous cells are often said to be more responsible for cancer patient’s death. Tumor cells develop drug resistance to chemotherapeutic drugs that lead to a failure or inefficient action of the drug on cancer cells and unregulated action on normal cells. The widely explored bio conjugation strategies are explored to advance the controlled drug delivery and duration of drug delivery, while targeting explicit locations of the body (such as tumors) for therapy, to get rid from drug resistance by the tumors. We aimed to develop bioconjugated silica nano assembly that improve anticancer drug targeting and tackle the drug resistance without moderate toxicological effects. In our preclinical toxicology experiments, we utilized the intended clinical administration route, i.e. intravenous injection, throughout the studies with the normal and HTC116/DR tumor-bearing mice models. The overall study revealed best strategy against drug resistance cancer cells and tissues developed by these nano assembly.<br/>The nano assembly is an encapsulation of various anticancer moieties in single modality to reduces the toxic drug concentration in normal host tissues and increases the concentration of active drug within the tumor. The present work achieved this goal and overcome the barrier of targeting nanomedicine using antibodies. Therefore, we developed here the alternative targeted multi cargo delivery systems which is important implications for future novel anticancer therapeutics. I<i>n vivo </i>trails with exact chemoresistance tumor model with different types of tumors such as breast tumor is currently being developed by our group to show the efficacy of present formulation on various cancers.<br/>

Self-assembled bio conjugated silica assembly in the treatment of drug resistance cancer

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.