Extradiol dioxygenase use metal chelation and oxygen activation to catalyze the cleavage of catecholic rings. The understanding of this powerful chemistry is limited by the substrates available for study. Electron withdrawing substituents on these catechols are attractive targets in semisynthetic applications of the extradiol cleavage products. To this end, the synthesis of 3, 4-dyhydroxycinnamic acid analogues with bromo, nitro, and cyano groups were designed. Progress towards the synthesis of these compounds will be discussed.<br/>

Synthesis of 3,4-dyhdroxyhydrocinnamic acid analogues to investigate dioxygenase activity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.