The hydrogen bond strengths were determined for various classes of compounds, including organic acids, alcohols/phenols, carboxylate bioisosteres, dicarbonyls, and amides, using 7-methyl-2-phenylimidazo[1,2-a]pyrazine-3-(7H)-one as a colorimetric sensor. Our findings further support the ineffectiveness of using pK<sub>a</sub> to estimate hydrogen bond strength. Additionally, full titrations were previously used to determine hydrogen bond strengths; however, from the compiled strength data, a simplified method for conducting the experiments was achieved. Single, double, or triple point measurements can be effectively employed to accurately determine hydrogen bond strengths.

Simplification of method for hydrogen bond strength determination of various hydrogen bond donors

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.