Artificial lipid bilayers are an important tool in the world of biointerfaces. However, a major impediment to the adoption of techniques involving biomembrane synthesis is their inherent instability and fragility. One method for reducing membrane fragility is by supporting the lipid bilayer with a network of actin filaments also called a MAC (minimal actin cortex). Such networks can be layered indefinitely, forming increasingly thick and dense networks upon the bilayer. While previous work on MAC formation focuses on a glass supported bilayer, recently our lab has transferred this procedure to bilayers painted across a small aperture. Transfer of the procedure to an aperture based bilayer allows for simultaneous electronic and fluorescent recordings. Simultaneous electronic and fluorescent recordings confirms the compatibility of MAC formation with techniques involving capacitance measurements, nanopore conductivity, along with many others.

Development of minimal actin cortices (MACs) on lipid bilayers for ion channel electrophysiological recordings

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.