At the point of intravenous dosing, most biologics are typically diluted with diluents such as saline and dextrose in infusion containers.  These infusion containers are typically manufactured with a plasticized polymer. These additive polymers lend flexibility and durability to the containers. There is a potential for these plasticizers to leach into the infusion solution. The objective here was to measure and quantify the amount of plasticizers leaching from IV bags and other infusion components that are in contact with various infusion formulation compositions and to evaluate what conditions/factors influences the leaching behavior.<br/>

Molecular interactions between drug product formulation excipients and infusion containers/components

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.