<br/>Single-use technologies were used to establish and demonstrate a 2000L live virus vaccine (LVV) candidate manufacturing process in an unfinished space with minimal utilities and short preparation time.  The commercial process for the LVV candidate is projected to require a 2000L production reactor followed by a purification train containing filtration and chromatography steps.  In the commercial production setting, this process will utilize automated large-scale chromatography skids and will require disposal of ~3000L of waste.  Prior to design and construction of the commercial facility, there was a need to perform shakedown lots in order to demonstrate the process at manufacturing scale, obtain data to inform Final Manufacturing Process (FMP) development, and provide information for the commercial facility design. Through the use of single-use technologies (SUT), the aggressive timeline for the shakedown lots was able to be met.<br/>

Bioprocess development: Using single-use technology to enable manufacturing scale shakedown lots

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.