The success of monoclonal antibody (mAb) drugs has encouraged the pharmaceutical industry to pursue high-productivity biologics manufacturing processes. The demand is driven by multiple factors, particularly growing competition and market uncertainty. In addition, there is increased demand to lower the cost of mAbs for the treatment of chronic conditions. While continuous chromatography technology has been developed to improve productivity using resin-based media, mAb purification still remains a critical bottleneck in the manufacturing process due to the slow processing speed of resins. This presentation highlights Purilogics’ recent progress on development of novel Protein A membrane chromatographic technology (PurexaTM-A). Beyond high binding capacity and fast processing speeds, we aim to deliver a differentiated product enabling a robust process over multiple cycles. In this presentation, we will demonstrate purification performance of our prototypes using a suite of CHO-derived monoclonal antibodies. Key quality attributes such as: host cell protein, DNA, and aggregate content of the purified antibody pool will be characterized along with mAb recovery. In addition, we will demonstrate reusability of the membrane with multiple-cycle bind-and-elute studies.

New tool for the next generation of antibody purification: Case study using novel protein A affinity chromatographic membrane technology

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.