As more companies move towards more diversified portfolios, drug manufacturing in biotech is evolving to require the use of different cell lines and the production of multiple types of complex proteins in the same facility.  As the products vary, the manufacturing modes and volume requirements change along with the regulatory landscape.  The need for scalable, flexible, and single-use manufacturing strategies is becoming increasingly important.  The poster will discuss case studies on 1) demonstrating the intensification of upstream process development and scalability to commercial manufacturing, 2) demonstrating combinations of rocking motion (RM) and stirred tank bioreactors (STR) coupled with process analytical technologies (PAT) that allow for multiple seed train and manufacturing scenarios using fed-batch, intensified, or perfusion cultures, 3) demonstrating the development of counterflow single-use centrifugation on a CHO fed-batch process with ~5g/l product titer, ~8% biomass, and ~ 90% viability to double the depth filtration performance for cell culture clarification, and 4) demonstrating the flexibility that the use of novel highly productive convective capture single-batch-mode devices offer, and analyze the possible processing space concerning overall processing time, number of cycles, bed volume, and COGs. Lastly, the poster will also discuss the importance of a fully integrated single-use platform as well as the connection from upstream to downstream processing.<br/>

Flexible intensified manufacturing strategies to support existing and facilities of the future

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.