Holmium (Ho) is an element that has recently shown promise in cancer therapy as a radionuclide material. The radioactive isotope holmium-166 (166Ho) can be generated by neutron activation of the 100% naturally abundant 165Ho. Suitable 166Ho carriers must present high holmium content, have low toxicity and be chemically and thermally stable (to withstand neutron-activation). Alternatively, radiosensitizers are compounds that decrease the amount of radiation required to kill cancer cells. Such materials include Nitric Oxide (NO) or Cisplatin. The focus of the work to be presented is the synthesis of Metal-Organic Frameworks (MOFs) with a dual functionality to incorporate both holmium and a radiosensitizer in their structure. Having both the radiation source and the radiosensitizer in the same material can localize and reduce the radiation necessary to treat cancer, thus decreasing the negative effects associated with radiation therapy. MOFs are crystalline nanostructures with functional pores built by the coordination between organic ligands and metal nodes. By carefully selecting the nature of the metal node and the organic functionalities in the ligand, the properties of the MOF can be tuned. In particular, results on different MOF structures with Holmium as the metal node will be discussed. The high coordination number of holmium in addition to the versatile coordination modes of the ligands resulted in a wide variety of structures. Discussion on the growth of thin films of these MOFs will also be covered. Finally, other attempts to incorporate holmium in other MOFs capable of storing NO will also be covered.

Dual functionality metal-organic frameworks for cancer therapy: Radionuclide/radiosensitizer carrier materials

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.