We have developed an all-polymeric nanoparticle as delivery scaffold for bioorthogonal catalysts. We synthesized polymeric backbones to generate nanostructured core-shell particles. In this approach the polymeric chains have been designed to present two distinct segments: a hydrophilic block and a hydrophobic one. In polar media these polymers self-assemble into stable nanoparticles with a hydrophobic core ideal for encapsulation of hydrophobic catalysts (see Figure 1). The synthetic strategies adopted for the preparation of the polymeric chains are based on controlled polymerizations, as reliable techniques to generate well-defined block copolymers. The bioorthogonal catalyst, a hydrophobic metal complex, is stably hosted in the nanoparticle core while the hydrophilic chains in the external shell provide stability to the particle in physiological environment. This system provides a platform for pro-drug activation, applicable for different therapeutic treatments, included multi-drug-resistant bacterial infections.

Core-shell polyzymes as an approach towards polymeric nanoparticles for intracellular bioorthogonal catalysis

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.