The evolution of proteins is affected by multiple factors, especially gene expression levels.  Other factors that were seemed like they might be important, like the degree of connectivity in metabolic pathways, are at best weakly associated with evolutionary rates.  However, studies also indicate that genes that code for enzymes evolve at different rates than genes that code for non-enzyme proteins and that features related specifically to enzyme active sites might play a role in the amino acid conservation in enzymes.  That is catalytic sites in enzymes add evolutionary constraints beyond the simple binding sites found in other proteins.  Interestingly, allosterically regulated enzymes contain both active sites and binding sites.  These enzymes also generally have important positions in metabolic pathways and through their allosteric regulation a level of connectedness not defined simply by their substrates and products.  This raises questions about the evolution of allosterically regulated enzymes and allosteric binding sites as to whether they behave differently than enzyme active sites and non-allosterically regulated enzymes.  I have carried out tests to identify differences in the amino acid content, conservation, and evolution in allosteric regulatory sites and active sites in metabolic enzymes.  In addition, differences between the amino acid content, evolution, and amino acid conservation of the allosterically regulated enzymes has been compared to enzymes that neighbor the allosterically regulated enzyme in metabolic pathways. <br/>

Evolution and amino acid conservation in allosterically regulated enzymes

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.