A sustainable protocol for the synthesis of oxazolines and oxazoles containing a fluoromethyl moiety by use of electrochemistry has been established. Thereby, hypervalent difluoroiodoarene (ArIF2) is generated in-situ by direct electrochemical oxidation of iodoarene (ArI) in Et3N*5HF and mediates the fluorocyclization of N-allyl- and N-propargylamides to fluoromethyl oxazolines and oxazoles, respectively. The fluorocyclization provides the synthesis of the heterocycle and the fluorination in a single step. Furthermore, this electrochemical approach is easy to conduct under constant current conditions and offers a green and safer alternative over conventional reagent-based pathways.

Fluorocyclization of N-allyl- and N-propargylamides by electrochemically generated ArIF2

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.