Electron paramagnetic resonance imaging (EPRI), the electronic spin analogue of magnetic resonance imaging (MRI), is capable of imaging chemical function, in contrast to conventional <sup>1</sup>H MRI. Metal complexes are an exciting potential next-generation probe for EPRI for at least two reasons. First, metal ions have a diverse chemical reactivity, enabling the design of new sensing pathways for imaging physiological chemistry. Second, metal ions (particularly high-spin ones) engender the use of safe, low-frequency microwaves for imaging, even at high field. Despite these advantages, however, metal complexes are untouched for the application. Indeed, even controlling the low-frequency EPR properties of metal ions to develop new imaging probes is impossible because design principles to do so do not exist. In this talk, we will present our first efforts toward said design principles, investigating the properties of a set of six-coordinate chromium complexes via low-frequency (safe for in vivo use) L-band (~1.2 GHz) EPR spectroscopy. Importantly, this work seeks to understand how to control EPR spectroscopic linewidth (a key functional property for utility) via chemical design of the ligand shell. In the long run, this effort will deliver crucial fundamental insight into next-generation magnetic resonance molecular probe design.

Toward metal-ion electron paramagnetic resonance imaging (EPRI) probes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.