X-Chem’s DNA-encoded discovery platform (DEX™) has been successful in identifying novel chemical binders across an array of target classes of therapeutic importance.  X-Chem has generated over 120 billion library compounds and continues to grow their libraries with new chemistries and process development, expanding the available chemical space.  By integrating common chemistries recognized in traditional organic synthesis such as acylation, reductive amination, Suzuki chemistry, and many others, we continue to develop proprietary chemistries to access lead-like chemical space with highly desirable physicochemical properties and diversity.  Herein we are able to demonstrate the various chemotypes of libraries that have been generated and the assembly process by which they have been developed, validated and synthesized, ultimately leading to desirable hits against screened targets.

DNA-encoded discovery platform exploring chemical space through library diversity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.