Carbon monoxide is an endogenous signaling molecule with physiological roles in mammals and therapeutic applications, especially in the area of anti-inflammation. Recent years have seen an intense interest in developing CO-based therapeutics, especially in the area of developing CO prodrugs for easy delivery. We report herein a system that cages CO in a small organic molecule wherein CO release is triggered by exposure to visible light, making it possible for skin application in the form of a lotion. Further, two CO molecules are released from each prodrug molecule, leading to CO delivery of high efficiency. The presentation will discuss the detailed chemistry and assessment of CO release kinetics.

Visible-light activated carbon monoxide prodrugs

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.