Since the beginning of humanity, people have been encountering problems with their health and well-being. So, it is crucial that the healthcare system is up-to-date and provides the most current and beneficial medication to suit the needs of each person. Unfortunately, many drugs are each year withdrawn from market due to risks to patients. Worldwide, research is being conducted to address some of the issues encountered with many of these drugs. One way to overcome some of these problems is to convert them into dual functional ionic liquids. Thioridazine, a phenothiazine antipsychotic drug, is one of the many medications discontinued due to its side effects such as severe cardiac arrhythmias. Lidocaine is a well-known antiarrhythmic drug. By combining the two drugs into one single compound, thioridazine’s adverse side effect can possibly be eliminated. This can be achieved as follows:  thioridazine cation, lidocaine cation, and docusate anion (a known ionic liquid forming ion) can be combined in various molar ratios to form new liquid state drugs with improved properties when compared to the discontinued drug. The new liquid state compounds will have the added advantage of existing in only one chemical form (with no polymorphic conversion as seen with solid-state drugs) while decreasing the number of drug administrations. Therefore, the research presented here focuses on the synthesis of new thioridazine medication in liquid form obtained by combining it with lidocaine in varying molar ratio (i.e., 0.5 to 0.5) as well as on determining its purity by using known spectroscopic methods.<br/> <br/>

Towards thioridazine drugs in liquid state: Synthesis and spectroscopic characterization

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.