1,2-dihydroisoquinolines are important structural motifs present in a wide range of compounds with desired biological activities. Additionally, they serve as precursors to isoquinolines. We have designed a synthesis of 1,2-dihydroisoquinolines in a one pot, copper-catalyzed reaction that allows for generation off the core and addition of varying external nucleophiles which become substituents on the 1,2-dihydroisoquinoline.

Copper-catalyzed approach to 1,2-dihydroisoquinolines

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.